Lysodren (mitotane) is used by veterinarians diagnosed with Cushing's Disease in dogs. Lysodren requires a prescription from your veterinarian and is sold per tablet. Lysodren is the Generic Alternative to Mitotane. Talk to your veterinarian if your pet is pregnant, or lactating. Tell your veterinarian if your pet has kidney or liver disease. Lysodren is a prescription medication used in dogs to treat Cushing's disease. Lysodren is effective in helping your pet's illness and is easy on your wallet.